Post-ENRICH Areas of Interest (AOIs)

High Level Clinically Vascular AOIs

1. Outcome Driven Analyses Related to Anterior Basal Ganglia (ABG)
   1. Factors impacting functional recovery in ABG
   2. Expanded understanding of scientific signals in ENRICH for ABG
   3. Predictors of surgical outcome in ABG – negative, neutral, or positive
      1. Size of ABG
      2. Earlier Intervention to ABG Removal
      3. Instrumentation Specific to ABG for Greater Volume Reduction

2. Prognostication in all ICH
   1. Exploration of current scores and scales in ICH
      1. Identification of potential alternate assessment measures
      2. Evaluation of score and scale predictors currently in use

High Level Operational Efficiency AOIs

1. Developing and implementing a protocol for surgical treatment within 24 hour
   1. Clinical treatment protocol for Lobar and/or ABG
   2. Operational Process (especially for ABG)
      1. ED to OR time reduction
      2. OR set up time reduction
      3. Surgical time reduction
      4. Post-operative ICU days and patient management

2. Anti-coagulation protocol adjustments
3. ERAS and ENRICH

High Level AOIs for Safety and Risk Assessment

1. Imaging and intervention studies for subcortical hemorrhages (ABG)
2. Combined risk assessment and narrowing patient selection (ABG)
3. Safety in acute stage or without clot stability scan
4. Impact of Andexxa – Pre-release and post release impact on ENRICH patients