Evidence is Mounting
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50,000+ Patient Lives Impacted
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35+ Presentations at National and International Neurosurgical Conferences
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250+ Peer-reviewed Publications and Abstracts
These independent publications show:
- Repeated Safety;
- Efficiency; and
- Reduced Surgical Morbidity
associated with a wide range of abnormalities when using NICO technologies as a standardized method for contributing to improved clinical outcomes.

ICH Evacuation Clinical Impact
Clinical Advantages
Using a repeatable approach (trans-sulcal, parafascicular) and technology (BrainPath for access and NICO Myriad NOVUS® to mechanically evacuate the clot) provides three clinical advantages for ICH evacuation:
- Intervention in an acute time period without clot stability1
- Effective hemostasis management using a bi-manual technique
- Consistent evacuation >90% of clot1,2,3,4
Selected Clinical Outcomes
- 98.2% median clot evacuation1
- mRS <3 in 63% of patients2
- <15mL EOT volumes in 94 of 98 patients studied1,2,3,4
- Statistically significant post-op GCS improvement1,3
- Mortality Improvement (vs pre-op ICH score)1,3
- Decrease in ICU length of stay from 12 to 4 days5
Selected Economic Outcomes
- Increased surgical options for patients vs medical management.
- Reduction in repetitive non-contrast CT scans.3
- Throughput
- 55% decrease in mechanical ventilation days.3
- 18% decrease in neuro-ICU LOS days, freeing-up neuro-ICU beds.3
- 47% decrease in cost per patient.3
Tumor & Brain Biopsy Clinical Impact
In a 2020 Meta-Analysis published in World Neurosurgery that included 29 publications meeting rigorous inclusion criteria, more than 280 patients were included in a review of current studies on use of MIPS with BrainPath. The outcomes not only confirmed the success of non-disruptive, trans-sulcal access and the ability to achieve microsurgical techniques and hemostasis management, but also the following:
Selected Clinical Outcomes
- Lower surgical morbidity / post-operative complications (8.3%) as compared to traditional craniotomy6
- 80.6% of cases achieved gross total resection6
- 100% gross total resection for colloid cyst6
- 100% success in achieving pathologic diagnosis for all biopsy cases6
Selected Economic Outcomes
- Several cohorts have reported shorter length of hospital stay with MIPS using BrainPath as compared to traditional craniotomy, with benefits of:
- Minimal wound disruption6
- Decreased risk of post-operative wound infection6
- Lower post-operative complications6


Economic Impact
Clinical paper shows substantial economic benefit to hospital.
- Greater than 50% average reduction in ICU length of stay5
- Average economic benefit to the hospital of $12,000 per patient for 28 patients5
- Net estimated benefit to the bottom line of $329,6595

Presentations by Sid Norton
Watch video abstract presented by Sid Norton.

Finance AVP for Pediatrics,
CFO Primary Children’s Hospital,
Intermountain Healthcare
Citations
- Bauer, et al.”Initial Single-center technical experience with the BrainPath system for acute Intracerebral hemorrhage evacuation” Operative Neurosurgery 2016
- Labib, et al, “The safety and feasibility of image-guided BrainPath mediated transsulcul hematoma evacuation: a Multicenter trial” Neurosurgery 4, April 2017: 515-524
- Sujijantarat, et al. “Trans-sulcal endoport assisted evacuation of supratentorial Intracerebral hemorrhage “Operative Neurosurgery 0:1-8,2017
- Rutkowski, M., Song, I., Mack, W. and Zada, G. Outcomes After Minimally Invasive Parafascicular Surgery For Intracerebral Hemorrhage: A Single-Center Experience. World Neurosurgery. 2019; 132:e520 e528.
- Shah,et al. Technology that achieves the Triple Aim. ClinicoEconomics and Outcomes Research. 2017;9 519-523
- Mansour S. et al The use of BrainPath Tubular Retractors in the Management of Deep Brain Lesions: A Review of Current Studies. World Neurosurg. (2020) 134:155-163