Below is a high level overview of various Areas of Interest (AOI) for the Investigator Initiated Study (IIS) program. Please ensure that your concept proposal falls within one or more of these areas. Concepts that are not designed to encompass the AOIs may be rejected without further review. However, concepts outside of the AOIs that represent ‘out of the box’ thinking and are ultimately of great interest, may be considered.
Enhanced Recovery After Neurological Surgery (ERANS)
In various surgical specialties, the concept of Enhanced Recovery After Surgery (ERAS) has been well defined and applied for improved patient recovery and outcomes. However, in the neurological surgery community, this concept lacks scientific support. As the complexity of the neurological surgeryspace poses heightened risks for patient recovery, many hospitals and administrators are seeking exploration into the concept of ERANS involving minimally invasive techniques. ERANS protocols that involve the inclusion of minimally invasive surgical devices with BrainPath and Myriad are of interest. Such proposals must include a provision for measuring patient outcomes (eg: length of stay, post-operative complications, costs, etc). Other economic outcome projects will be considered.
Scientific Justification of “Why Access Matters”
Understanding the effect of neurosurgery on access and fascicular anatomyis paramount. While imaging technology improvements have led to greater knowledge of the connectivity and critical function of white matter tracts, the effect of minimally disruptive surgery on the structure and function of the brain is lacking.Imaging coupled with minimal disruption surgical technologies may preserve these critical white matter tracts and reduce post-operative deficits. Study proposals that address and document pre-and post-surgical changes in fascicular anatomy and white matter tracts following minimally invasive surgery using BrainPath as well as documentation of post-surgical deficits/improvements are of interest. Basic science, animal studies and clinical proposals will be considered.Patient populations of interest are adults and pediatrics.
Disease State Applications
A greater understanding of the pathophysiology, genetics, molecular biology and/or metastatic spread and recurrence of primary and secondary brain tumors is critical to fostering improved patient outcomes and tailoring treatment strategies.In an effort to advance knowledge surrounding subcortical and invasive neurological disease, proposals designed to investigate lesion removal and tissue preservation using BrainPath, Myriad and/or the Tissue Preservation System (TPS) are of interest. Laboratory science, animal models and clinical proposals will be considered.